Iasidi yeHyaluron (HA) yimolekyuli yomlingo esetyenziswa kakhulu kwimimandla yeubuhlekunye namayeza.Ukufunyanwa kwayo kunye nenkqubo yophuhliso ithwala iinzame ezingagungqiyo kunye nokwenziwa kwezinto ezintsha zobuchwepheshe kwizazinzulu.Eli nqaku liza kuhlolisisa imvelaphi, imvelaphi yembali kunye nophuhlisoi-hyaluronic acidngenkulungwane yama-20, etyhila uhambo olungaqhelekanga lwale molekyuli.

Iziphumo zomthombo:

Eyokuqala yafunyanwa ngowe-1934, xa uKarl Meyer, ugqirha wamehlo kwiYunivesithi yaseColumbia, kunye nomncedisi wakhe uJohn Palmer bakhetha i-polysaccharide ephezulu yemolekyuli equlethe i-uronic acid kunye neeshukela ze-amino kumzimba we-vitreous wamehlo eenkomo.Oku kufunyanisiweyo kuphawula ukungena ngokusemthethweni kwei-hyaluronic acidkwizazinzului-horizons.Ekubeni i-uronic acid-containing component ikhutshwe kumzimba we-vitreous, i-substance ibizwa ngegamaHyaluronic acid, ekwabizwa ngokuba yii-hyaluronic acid.Emva kwexesha elifutshane ukusuka kwi-1948 ukuya kwi-1951, iikhemisti ezininzi zaqala ukufunda isakhiwo se-hyaluronic acid.

Ixesha elitsha leendlela zokukhupha:

Kwiminyaka ye-1960, kunye nenkqubela phambili yesayensi kunye neteknoloji, abaphandi baqala ukusebenzisa iindlela zokukhupha izicubu ukuvelisa i-hyaluronic acid.Le nkqubo ibandakanya ukukhupha i-hyaluronic acid kwizicubu zezilwanyana, kodwa yayibiza kwaye ayizange ifumane ingqwalasela eninzi kunye nesicelo ngelo xesha.Nangona kunjalo, ukuphuhliswa kwale ndlela kuye kwakhuthaza uphando olongezelelweyo kwi-hyaluronic acid kwiinkalo zonyango kunye ne-biology, ibeka isiseko sokusetyenziswa kwayo ngokubanzi kwixesha elizayo.

Ukwenziwa kwezinto ezintsha kwiindlela zokubilisa:

Inguqulelo yokwenyani yenzeke ngeminyaka yoo-1980, xa iShiseido yaseJapan yaqala yasebenzisa ukubilisa ukuvelisa iasidi yehyaluronic.Le ndlela yokuvelisa entsha ayiphuculi kuphela ubunyulu bei-hyaluronic acid, kodwa ikwanyusa kakhulu isivuno sayo, iyenza ibe yi-biomaterial eyaziwayo.Ukuqaliswa kweendlela zokuvutshelwa kuye kwandise ngakumbi amasimi okusetyenziswa kwe-hyaluronic acid, kuqukaubuhle, amayeza kunye neenkqubo zokuhanjiswa kweziyobisi.

Ixesha legolide lobuhle kunye neyeza:

Njengoko iteknoloji yokuvelisa i-hyaluronic acid iqhubeka nokuphucula, kwinkulungwane yama-21, ngokuthe ngcembe ibe yinkwenkwezi.isithakokwiinkalo zobuhle kunye neyeza.Kwizinto zokuthambisa, i-hyaluronic acid isetyenziswa ngokubanzi njengento yokuzalisa ukugudisa imibimbi kunye nokuphuculaukunwebeka kwesikhumba.Kwiyeza, i-hyaluronic acid isetyenziswa kwiindawo ezifana nesifo samathambo, utyando lwamehlo, kunye nokupholisa amanxeba, okubonisa iziphumo ezigqwesileyo zeklinikhi.

Isiphelo:

Uhambo lwembali lwe-hyaluronic acid luyamangalisa, ukusuka ekufumaneni kwayo okokuqala ukuya kuphuhliso lweendlela zokutsalwa ukuya ekuqalisweni kweendlela zokubilisa, iasidi ye-hyaluronic iyaqhubeka nokuvela ukuze ibonelele ngezisombululo eziphezulu kuluntu.zokuthambisakunye neemfuno zonyango.Le molekyuli imangalisayo iya kuqhubeka idlala indima ephambili kuphando lwezenzululwazi kunye nokusebenza kwezonyango, ibeka isiseko esiluqilima sokwenziwa kwezinto ezintsha kunye nophuhliso kwixesha elizayo.