I-PGA kunye ne-HA: Uphuculo lwe-Synergistic, yithi Sala kakuhle ukuncamathela, ukufuma kunye ne-Antioxidant Duet

#Intshayelelo

I-Sodium polyglutamate (PGA)yipolima enyibilikayo emanzini eveliswa yiukuvundiswa kwemicrobial.Isetyenziswa ngokubanzi kwiukhathalelo lolusuiimveliso kunyeizinto zokuthambisangenxa yezinto ezigqwesileyo zokuthambisa kunye neempawu ezisebenzayo.Eli nqaku liza kwazisa umthombo, ubume beekhemikhali, iimpawu kunye nokusetyenziswa kwesodium polyglutamatekwiimveliso zokunakekelwa kwesikhumba ngokweenkcukacha.

#Umthombo kunye noLwakhiwo lweMichiza

I-sodium polyglutamateyaqala ukufunyanwa kwi-natto, ukutya okuqhelekileyo kwaseJapan.Isilika ebonakala kakhulu kwinatto yiPGA.Lo mxube wenziwa ipolymerized ukusuka kwi-asidi ye-glutamic yendalo kunye neyonakalayo kwaye iveliswa ngokubiliswa kwe-Bacillus subtilis.I-Bacillus subtilis luhlobo lwe-GRAS oluvunyiweyo kwihlabathi liphela, oluphuma ngokwendalo kwaye lukhuselekile kumzimba womntu.

Ulwakhiwo olusisiseko lwePGAyenziwe nge-5000-10000 ye-glutamic acid iimolekyuli ezenziwe ipolymerized ngokusebenzisaγ-iibhondi zeamide.I-molecule iqulethe inani elikhulu lamaqela e-polar afana ne-hydroxyl kunye namaqela e-carboxyl, anokwenza iibhondi ze-hydrogen ngaphakathi naphakathi kweeamolekyu, ngaloo ndlela zibophe umthamo omkhulu wamanzi kunye nokuphucula kakhulu umphumo wayo wokufuma.

# Iimpawu kunye nesiphumo

1. **Ukusebenza okugqwesileyo kokuthambisa**: I-PGA inokufunxa kwaye itshixe isixa esikhulu samanzi, iphucule kakhulu ukuhanjiswa kolusu.Xa isetyenziswa kunyei-sodium hyaluronate (HA), inokwandisa ixesha lokuthambisa i-HA, inciphise ukunamathela kwayo, kwaye yenza ulusu luzive lungokwemvelo kwaye lulula.

2. **Umsebenzi we-Antioxidant**: I-PGA inomsebenzi we-antioxidant, inokukhupha ii-radicals zamahhala, kwaye ikhusele ulusu kumonakalo we-oxidative.Uphononongo lubonise ukuba i-PGA ene-molecular weight ye-1.4 yezigidi ze-Da yenza ngcono kancinci kune-PGA kunye ne-molecular weight ye-1 yezigidi ze-Da ekukhupheni i-DPPH i-radicals yamahhala.

3. **Yandisa umxholo wendalo yokuthambisa (NMF) eluswini**: I-PGA inokukhuthaza ukuveliswa kwe-NMF eluswini, iphucule isakhono esingokwemvelo sokuthambisa ulusu, kwaye ifezekise isiphumo sesondlo esinzulu.

4. **Ukuba mhlophe kunye nokuchasa ukuguga**: I-PGA inokulawula ngobumnene umsebenzi we-tyrosinase, ukulibazisa ukubunjwa kwamabala, kwaye ngexesha elifanayo liphucule ukuzinza kwe-HA elukhumbeni, ukwandisa umxholo we-HA, kwaye ufezekise umphumo wokuba mhlophe kunye nokuchasana nokuguga.

#Ubunzima beMolekyuli kunye nesicelo

Ngokobunzima bemolekyuli, i-PGA inokwahlulwa ibe ziindidi ezintathu: ubunzima obuphezulu bemolekyuli, ubunzima bemolekyuli obuphakathi kunye nobunzima obuphantsi bemolekyuli, nganye ineempawu ezahlukeneyo kunye nokusetyenziswa:

- **PGA-HMW (ubunzima obuphezulu bemolekyuli,>700kDa)**: i-moisturizing ehlala ixesha elide, ukwenza ifilimu ecocekileyo ebusweni besikhumba, iphucula kakhulu umphumo wokunyusa.

- **PGA-LMW (ubunzima bemolekyuli obuphakathi, 70-150kDa)**: ukuthambisa kunye nokwenza mhlophe, ukuphucula ukuqaqamba kwesikhumba kunye nokunwebeka.

- **PGA-Oligo (ubunzima obuphantsi bemolekyuli, <10kDa)**: ukondla okunzulu, ukufikelela ngokuthe ngqo kwi-basal layer, ukukhuthaza ukuveliswa kwe-NMF kunye nokufunxa izondlo.

# Iingcebiso zokuSebenza kunye nokusebenzisa

I-PGA ilungele ukuthambisa, ukulwa nokuguga kunye neemveliso ezimhlophe, kunye noxinzelelo olucetyiswayo lwe0.1% ukuya kwi-1%.I-Anti-ionic emulsifiers kufuneka isetyenziswe kangangoko kunokwenzeka kwifomula yokwandisa umphumo wePGA.

#Isiphelo

Njengendalo, ekhuselekileyo kunye ne-biopolymer esebenzayo,i-sodium polyglutamate (PGA)ibonisa amandla amakhulu okusetyenziswa kwiimveliso zokunakekelwa kwesikhumba kunye nezithambiso.Iimpawu zayo ezibalaseleyo zokuthambisa, umsebenzi we-antioxidant kunye neenzuzo ezininzi kwimpilo yolusu zenza ukuba ibe yinto ebalulekileyo kwiimveliso zokhathalelo lwesikhumba zanamhlanje.Ngokunzulu kophando kunye nokuqhubela phambili kwetekhnoloji yesicelo,PGAkulindeleke ukuba idlale indima ebalulekileyo kwiinkalo ezininzi kwaye izise izinto ezintsha kunye nophuhliso kubuchwepheshe bokunakekelwa kwesikhumba.